Effect of a MVM Dietary Supplement on Indices of Human Health

Inclusion Criteria: * Body Mass Index of 29.9 to 40 kg/m2 ±1 kg/m2 * Waist measurement for males ≥ 102 cm (40 inches) or for females ≥ 89 cm (35 inches) * two or more of the following risk factors: * Elevated blood pressure ( 130/85 mm Hg) * Fasting elevated triglycerides \> 1.69 mmol/L ( 150 mg/dL) * Elevated fasting glucose \> 5.56 mmol/L ( 100 mg/dL) and \<7.0 mmol/L (\<126 mg/dL) * Low HDL cholesterol \<1.29 mmol/L ( 50 mg/dL) for females, and \<1.03 mmol/L ( 40 mg/dL) for males * Not currently taking a multivitamin/mineral, antioxidant supplement, or other dietary supplements or are willing to wash out for 4 weeks before enrollment Exclusion Criteria: * Pregnant and/ or lactating females or females trying to become pregnant * Use of lipid lowering medications * Lipid lowering OTC or herbal supplements within 3 weeks of enrollment * Use of conventional multivitamin/mineral, antioxidant supplements or other dietary supplements within four weeks prior to enrollment * Insulin-dependent Type I and Type II diabetics * Diabetic men \> 45 years and diabetic women \> 55 years * Metformin or other diabetes medications are prohibited in this study * Type II diabetes controlled by diet and/or exercise * Elevated blood pressure ( 160/95 mm Hg) at screening * Individuals with a history of coronary artery disease, previous myocardial infarction, peripheral vascular disease, or atherosclerosis * Men above 50 years and women above 60 years who have a 10-year risk of cardiovascular event FRS between 10% and 19% (inclusive) at screening and who present with one of the following LDL-C \> 3.5 mmol/L, TC/HDL-C ratio \> 5.0, or hs-CRP \> 2 mg/L * Individuals with a 10-year risk of cardiovascular event FRS \< 10% at screening and present with LDL-C \> 5.0 mmol/L or TC/HDL-C ratio \> 6.0 * Participants taking blood thinners * Participants with stomach ulcers, gall stones, or bile duct obstruction