NCT03490227 - Measurement of Body Fat in Infants | Crick

Overview

Up to 10 infants will complete the study aimed to establish a technique for measuring whole body adiposity and brown adipose tissue in infant subjects using dual energy x-ray absorptiometry and magnetic resonance imaging, respectively.

Study Type

OBSERVATIONAL

Enrollment

10

Conditions

Brown Adipose Tissue Body Composition

Eligibility

Sex: ALLMin age: 14 DaysMax age: 28 DaysHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy, full-term infant * aged 14-28 days at Visit 1 Exclusion Criteria: * born preterm (\<37 weeks gestation) * implanted metal or electronic objects that render MRI unsafe * unable to complete 2 clinic visits 1-10 days apart at Pennington Biomedical Research Center

Locations (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Outcomes

Primary Outcomes

Whole Body Fat Mass

Whole body fat mass will be measured in infant subjects using dual energy x-ray absorptiometry.

Time frame: 1 day

Average Brown Adipose Tissue Volume at First Visit

Magnetic resonance imaging were traced for lipid: water ratio in the supraclavicular region. Brown adipose tissue volume was calculated by summing all brown adipose tissue volume in the supraclavicular region with a lipid: water ration (or fat signal fraction) between 10-50%.

Time frame: 1 day

Average Brown Adipose Tissue Volume at Second Visit

Magnetic resonance imaging were traced for lipid: water ratio in the supraclavicular region. Brown adipose tissue volume was calculated by summing all brown adipose tissue volume in the supraclavicular region with a lipid: water ration (or fat signal fraction) between 10-50%.

Time frame: 1 day

Secondary Outcomes

Average Fat Signal Fraction of Brown Adipose Tissue at First Visit

Magnetic resonance imaging scans were traced for lipid: water ratio in the supraclavicular region. Fat signal fraction is defined as the lipid: water ratio found in the lipid tissues in the supraclavicular region. Only traced lipid tissues (between 10-50%) were included in the average fat signal fraction because only traced lipid tissues were classified as brown adipose tissue.

Time frame: 1 day

Average Fat Signal Fraction of Brown Adipose Tissue at Second Visit

Magnetic resonance imaging scans were traced for lipid: water ratio in the supraclavicular region. Fat signal fraction is defined as the lipid: water ratio found in the lipid tissues in the supraclavicular region. Only traced lipid tissues (between 10-50%) were included in the average fat signal fraction because only traced lipid tissues were classified as brown adipose tissue.