RNA Sequencing Analysis in Large Vessel Occlusion Stroke DATA Bank

Inclusion Criteria: 1. Informed consent as documented by signature 2. Age ≥ 18 to \< 86 years 3. Clinical signs consistent with an acute ischemic stroke 4. Neurological deficit with a NIHSS of ≥ 8 and \< 30 5. Patient is eligible for intravenous thrombolysis 6. Patient is eligible for endovascular treatment 7. Randomization no later than 4 hours 15 minutes after stroke symptom onset and initiation of IV t-PA must be started within 4 hours 30 minutes of stroke symptoms onset (onset time is measured from the time when the subject was last seen well) 8. Occlusion (TICI 0-1) of the intracranial internal carotid artery (ICA), the M1 segment of the middle cerebral artery (MCA), or both confirmed by CT or MR angiography, accessible for MT 9. Core-infarct volume of Alberta Stroke Program Early CT Score (ASPECTS) greater than or equal to 6 (≥6) based on baseline CT or MR imaging (MRI) Exclusion Criteria: 1. Acute intracranial hemorrhage 2. Any contraindication for IV t-PA 3. Pre-treatment with IV t-PA 4. In-hospital stroke 5. Pregnancy or lactating women. A negative pregnancy test before randomization is required for all women with child-bearing potential. 6. Known (serious) sensitivity to radiographic contrast agents, nickel, titanium metals, or their alloys 7. Known current participation in a clinical trial (investigational drug or medical device) 8. Renal insufficiency as defined by a serum creatinine \> 2.0 mg/dl (or 176.8 µmol/l) or glomerular filtration rate (GFR) \< 30 mL/min or requirement for hemodialysis or peritoneal dialysis 9. Severe comorbid condition with life expectancy less than 90 days at baseline 10. Known advanced dementia or significant pre-stroke disability (mRS score of ≥2) 11. Foreseeable difficulties in follow-up due to geographic reasons (e.g. patients living abroad) 12. Comorbid disease or condition that would confound the neurological and functional evaluations or compromise survival or ability to complete follow-up assessments. 13. Subject currently uses or has a recent history of illicit drug(s) or abuses alcohol (defined as regular or daily consumption of more than four alcoholic drinks per day). 14. Known history of arterial tortuosity, pre-existing stent, other arterial disease and/or known disease at the femoral access site that would prevent the device from reaching the target vessel and/or preclude safe recovery after MT 15. Radiological confirmed evidence of mass effect or intracranial tumor (except small meningioma) 16. Radiological confirmed evidence of cerebral vasculitis 17. CTA or MRA evidence of carotid artery dissection 18. Evidence of additional distal intracranial vessel occlusion in another territory (i.e. A2 segment of anterior cerebral artery or M3, M4 segment of MCA) on initial NCCT/MRI or CTA/MRA