Limb Girdle Muscular Dystrophy Type 2E Recruitment Study

Inclusion Criteria: * Age 3-15 inclusive * Males or females of any ethnic group * SGCB DNA gene mutations at both alleles or suspected to have LGMD2E based on family and medical history. If suspected, genetic testing will be performed to confirm diagnosis. * Weakness demonstrated based on history of difficulty running, jumping and climbing stairs * Ability to complete 100MW timed test within 30-90% predicted * Perform assessments to the best of their ability with reliable results as deemed by the evaluator. * Ability to attend scheduled appointments * Ability to provide informed consent (or assent for ages 9-15) Exclusion Criteria: * Confirmed diagnosis of neuromuscular disorder other than LGMD2E * Has a medical condition or extenuating circumstance that, in the opinion of the investigator, might compromise the subject's ability to comply with the protocol required testing or procedures or compromise the subject's wellbeing, safety, or clinical interpretability * Subjects with AAVrh74 binding antibody titers \> 1:400 as determined by ELISA immunoassay. If endpoint titer is positive at screening, testing may be repeated in 1 month. Antibody testing will be performed on a separate study (IRB17-01101). * Diagnosis of (or ongoing treatment for) an autoimmune disease