Hyperuricemia and Left Ventricular Diastolic Function

National Defense Medical Center, Taiwan67 enrolled

Overview

Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained unclear. The aim of the present study focuses on the association among hyperuricemia, diastolic dysfunction and inflammatory biomarkers in apparently healthy individuals with metabolic syndrome

Apparently healthy individuals with metabolic syndrome were prospectively and consecutively enrolled since August 2017. Blood samples were obtained after participants are fasting for at least 12 hours, including serum uric acid, high-sensitivity C-reactive protein, high-sensitivity interleukin-6, tumor necrotizing factor alpha, fasting glucose, glycosylated hemoglobin, insulin, lipid profile, creatinine, alanine aminotransferase, sodium, potassium, and calcium. All echocardiographic parameters were measured in accordance with the American Society of Echocardiography guidelines.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hyperuricemia Metabolic Syndrome Left Ventricular Diastolic Dysfunction

Interventions

hyperuricemiaDIAGNOSTIC_TEST

serum uric acid of 7mg/dl or more in men or 6mg/dl or more in women

Eligibility

Sex: ALLMin age: 20 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age between 20 to 75 years 2. Metabolic syndrome Exclusion Criteria: 1. Left ventricular ejection fraction \<40% 2. Severe valvular heart disease 3. Significant structure heart diseases such as hypertrophic, dilated, infiltrative or restrictive cardiomyopathy, or congenital heart disease 4. Persistent or chronic atrial fibrillation 5. Status post cardiac surgery, including coronary artery bypass surgery of valve intervention 6. Status post intra-cardiac device implantation 7. Chronic obstructive pulmonary disease 8. Severe anemia 9. An obvious systemic disease that interferes left ventricular diastolic dysfunction such as acute coronary syndrome

Locations (1)

Tri-service General Hospital, songshan branch

Taipei, Songshan Dist., Taiwan

Outcomes

Primary Outcomes

Left ventricle diastolic dysfunction with elevated left atrial pressure

The contemporary definition of left ventricular diastolic dysfunction with elevated left atrial pressure is mainly \>50% positive of the following criteria: (1) average E/e' ≥14 (2) left atrial volume index \>34 ml/m2 (3) tricuspid regurgitation velocity \>2.8 m/s

Time frame: 1 day

Secondary Outcomes

high-sensitivity C-reactive protein

determined by Latex enhanced immunoturbidimetric，ADVIA 1800，ADVIA Chemistry XPT，Dimension RXL，SIEMENS，AU 640，Beckman Coulter

Time frame: 1 week

high-sensitivity interleukin-6

determined by elisa enzyme-linked immunosorbent assay, R \& D system

Time frame: 1 month

tumor necrotizing factor alpha

determined by elisa enzyme-linked immunosorbent assay

Time frame: 1 month

Data from ClinicalTrials.gov

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