Addictive Potential of LCCs in Dual Users

UConn Health65 enrolled

Overview

This study is about whether or not little cigars and cigarillos cause or maintain addiction, and if flavors, such as fruit, make them more addictive. The purpose of this study is to understand the addiction potential of little cigars and cigarillos compared to cigarettes in young adults who smoke both products. This study will also look at the differences between men and women. In the rest of this form, little cigars or cigarillos will be referred to as LCCs.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Tobacco Use Disorder Dual Tobacco Use Tobacco Dependence Smoking Smoking, Cigar

Eligibility

Sex: ALLMin age: 18 YearsMax age: 34 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Current regular dual user of little cigars/cigarillos (LCCs) and cigarettes, defined as: (a) report smoking cigarettes on ≥ 8 of the past 30 days, and (b) report smoking unaltered LCCs (without marijuana) on ≥ 8 of the past 30 days. * Able to speak, read and understand English * Age 18-34 years of age * Stable residence (not planning to move during study period) * Not intending to quit smoking cigarettes or LCCs within the next 2 weeks * An expired carbon monoxide (CO) level of at least 4 ppm of expired air to verify smoking status Exclusion Criteria: * Pregnant for women (verified by urine pregnancy test at Visits 1 and 2) * Current use of (or plans to use in the next 2-3 weeks) nicotine replacement products or cessation products (e.g., bupropion) to minimize confounding effects of another product) * Positive breath alcohol screen (breath alcohol level (BAL) \> 0 g/ml; one re-test allowed; assessed at Visits 1, 2, and 3) * Illicit drug use other than marijuana (verified by positive drug toxicology test at Visits 1 and 3; one re-test allowed) * Met criteria for Cannabis Dependence assessed by the Cannabis Use Disorders Identification Test-Revised (CUDIT-R)

Outcomes

Primary Outcomes

Demand Elasticity

Hypothetical consumption of LCCs as prices increase. These are the model-adjusted predicted mean values of elasticity, adjusted for covariates. It is the expected change in consumption for a one unit change in price.

Time frame: Post-treatment (after being assigned to use it for 7 days)

Demand Intensity

Hypothetical consumption when free. These are the model-adjusted predicted mean values of intensity, adjusted for covariates.

Time frame: Post-treatment (after 7 days of being assigned to condition)