The Neuroprotective Effect of Remote Ischemic Conditioning in Aneurysm Coiling Therapy

Inclusion Criteria: * Age 18 years or older * Unruptured brain aneurysm deemed suitable for neuroendovascular repair * Normal baseline brain MRI * Female subjects of childbearing potential have a negative pregnancy test. * Signed informed consent prior to entering study Exclusion Criteria: * Dissecting or mycotic brain aneurysm. * Planned endovascular vessel sacrifice as the primary modality for aneurysm treatment * Severe, sustained hypertension (SBP \> 185 mmHg or DBP \> 110 mmHg) * Contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs * Pre-morbid modified Rankin scale score of greater than 1 * Patients with a pre-existing neurological or psychiatric disease that would confound the neurological or functional evaluations * Patients who are unable to have an MRI scan for any reason. * Currently participating or previously participated in any investigational drug or device study within 6 months