Early Stage Retinal Abnormalities in Type 1 Diabetes, Screened With OCT Angiography.

Centre Hospitalier Universitaire Dijon520 enrolled

Overview

The improvement of imaging techniques in ophthalmology has made it possible to carry out a precise non-invasive study of the retinal microvascular network and to detect early abnormalities in retinal disorders. The presence of such early retinal abnormalities remains poorly known during type 1 diabetes and may be detected with OCT-angiography. Furthermore, the association with glycemic variability, likely to have deleterious effects on microvessels, has never been studied.

Study Type

OBSERVATIONAL

Enrollment

520

Conditions

Type 1 Diabetes Patients

Interventions

Retinal imaging assessmentPROCEDURE

* OCT-angiography * Automated measurement program: size of the avascular zone and perifoveolar vascular density of the superficial capillary plexus * Eye fundus photography: macular image * Measurement of the fractal dimension of the retinal foveolar retina from photographs of the fundus

blood glucose holterPROCEDURE

for 40 subjects, implantation of a blood glucose holter monitor for 7 days

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: For the patient group * Patient who has given consent * Type 1 diabetic patient, no retinopathy For the healthy control group * Patient who has given consent * Non-diabetic patient For dyslipidemic control group: * Person who has given consent * Person with familial dyslipidemia Exclusion Criteria: For the patient group * Presence of diabetic retinopathy * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a health insurance scheme For the healthy control group * Ophthalmological history (vascular and degenerative macular conditions) * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a social security scheme For dyslipidemic control group: * Ophthalmological history (vascular and degenerative macular conditions) * Protected patient: * Minor patient * Pregnant, parturient or breastfeeding woman * Patient under legal protection (guardianship, curatorship, court decision) * Patient unable to express consent Person not affiliated to a social security scheme

Locations (1)

CHU Dijon Bourgogne

Dijon, France

RECRUITING

Outcomes

Primary Outcomes

surface of the central retinal avascular zone

measurement of superficial capillary plexus

Time frame: inclusion

Data from ClinicalTrials.gov

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