Carcinoid Heart Disease (CHD) is a rare form of heart disease, occurring in over 50% of the patients with carcinoid syndrome. Pathophysiology, prognostic factors of development of Carcinoid Heart Disease and progression of disease remain unclear. This observational multicenter cohort study is designed to study the occurrence of Carcinoid Heart Disease in patients with differentiated carcinoid tumors, to describe numerous factors influencing the occurrence, severity, progression and long-term survival of patients with Carcinoid Heart Disease. Basic informations and detailed diagnosis informations (oncological and cardiac parameters), are collected by professional doctors. Clinical outcomes (onset of Carcinoid Heart Disease, cardiac surgery, related death) will be followed up every year or every six/three months if clinically indicated.
Study Type
OBSERVATIONAL
Enrollment
670
Patient at high risk of Carcinoid Heart Disease (metastatic ileum or bronchial well-differentiated neuroendocrine tumors, patients with high level of urinary 5HIAA or with carcinoid syndrome) are followed with annual echocardiography to detect the occurrence of carcinoid heart disease. In case of documented Carcinoid Heart Disease, a six or three months' cardiac follow-up is necessary to evaluate the progression and the severity of the disease. Investigators collect the data of clinical parameters (flushes, diarrhea, …) biological parameters (urinary 5HIAA, NT-ProBNP …) and cardiac parameters that may influence the occurrence, severity and progression of Carcinoid Heart Disease.
CHU Amiens
Amiens, France
CHU Angers
Angers, France
CHU Bordeaux - Hopital Haut-Lévèque
Bordeaux, France
APHP Beaujon
Clichy, France
CHU Dijon
Dijon, France
GHICL Lille
Lille, France
Centre Oscar Lambret
Lille, France
CHRU Lille
Lille, France
Hôpital Edouard HERRIOT, Institut du Cancer - Hospices Civils de Lyon
Lyon, France
Institut Paoli-Calmettes
Marseille, France
...and 9 more locations
Carcinoid Heart Disease
Percentage of patients with carcinoid heart disease at diagnosis and during follow-up (carcinoid heart disease diagnosis will be assessed by an annual echocardiography).
Time frame: 10 years (at the end of study)
Cardiac surgery
Percentage of patients requiring cardiac surgery for the cardiac carcinoid heart disease
Time frame: 10 years (at the end of study)
5HIAA levels
Correlation between urinary 5HIAA levels at diagnosis and occurrence of carcinoid heart disease
Time frame: 10 years (at the end of study)
Survival
Overall survival in patents with and without carcinoid heart disease
Time frame: 10 years (at death or at the end of study)
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