A Window of Opportunity Trial: Avelumab in Non-metastatic Muscle Invasive Bladder Cancer

Inclusion Criteria: * Have undergone TURBT showing newly diagnosed muscle invasive UCB (mixed histology is allowed if the predominant histology is UCC) within 6 weeks prior to cycle 1, day 1 of treatment. * No prior systemic treatment for muscle invasive UCB * Clinical T2-T4a disease * No evidence of clinically positive lymph nodes or distant metastasis on computed tomography (CT) scans of chest and CT or magnetic resonance imaging (MRI) studies of the abdomen/pelvis. Imaging must be within 90 days of registration. * Male or female subjects aged ≥ 18 years old. * Must have adequate kidney, liver, and bone marrow function within 30 days of registration, as follows: * Absolute neutrophil count (ANC) ≥ 1.5 × 109/L * platelet count ≥ 100 × 109/L * hemoglobin ≥ 9 g/dL (may have been transfused) * Total bilirubin level ≤ 1.5 × ULN * AST and ALT levels ≤ 2.5 × ULN * Estimated creatinine clearance ≥ 30 mL/min according to the Cockcroft-Gault formula * Negative serum or urine pregnancy test at screening for women of childbearing potential (WOCBP), within 30 days of registration. * Both male and female subjects must agree to use highly effective contraception (see Section 6.1 Table 8) while receiving avelumab and for at least 60 days after last avelumab treatment if the risk of conception exists. Female patients must agree to inform study coordinator or investigator immediately if they think they have become pregnant during the study. * Must have FFPE tissue available from the TURBT, and patient must consent to the use of tissue specimens from TURBT and RC for the study. * Patients must be ineligible for cisplatin-based NAC. Ineligibility criteria include: creatinine clearance \< 60 ml/min by Cockcroft-Gault formula, CTCAE grade ≥ 2 hearing loss, CTCAE grade ≥ 2 neuropathy, and at discretion of medical oncologist. * Must be eligible for RC in the opinion of the treating investigator, and willing to undergo this procedure. * ECOG performance status (PS) score of 0-2 * Signed informed consent form. Exclusion Criteria: Patients must not have any of the following: * IMMUNOSUPRESSANTS: Current use of immunosuppressive medication or within 4 weeks of C1D1, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. Systemic corticosteroids at physiologic doses ≤ 10 mg/day of prednisone or equivalent; c. Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication). * AUTOIMMUNE DISEASE: Active autoimmune disease that might deteriorate when receiving an immuno-stimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment are eligible. Patients with type I diabetes or hypo- or hyperthyroidism should be on stable doses of medications for participation. * ORGAN TRANSPLANTATION: Prior organ transplantation including allogenic stem-cell transplantation. * INFECTIONS: Active infection requiring systemic therapy. * HIV/AIDS: Known history of testing positive for HIV or known acquired immunodeficiency syndrome. * HEPATITIS: Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection at screening (positive HBV surface antigen or HCV RNA if anti-HCV antibody screening test positive) * VACCINATION: Vaccinate within 4 weeks of the first dose of avelumab and while on study drug is prohibited except for administration of inactivated vaccines * HYPERSENSITIIVTY TO STUDY DRUG: Known prior severe hypersensitivity to investigational product or any component in its formulations, including known severe hypersensitivity reactions to monoclonal antibodies (NCI CTCAE v4.03 Grade ≥ 3) * CARDIOVASCULAR DISEASE: Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (\< 6 months prior to enrollment), myocardial infarction (\< 6 months prior to enrollment), unstable angina, congestive heart failure (≥ New York Heart Association Classification Class II), or serious cardiac arrhythmia requiring medication. * Other severe acute or chronic medical conditions including colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis or psychiatric conditions including recent (within the past year) or active suicidal ideation or behavior; or laboratory abnormalities that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study. * Relapsed MIBC (all patients participating in the study should be newly diagnosed) * Concomitant UCC outside the bladder (e.g., ureter, urethra or renal pelvis) * Underlying immune disorder (e.g., combined variable immunodeficiency syndrome) * Erythropoietin receptor agonists within 30 days prior to enrollment. * G-CSF, GM-CSF or TPO mimetics during the study period or within 3 weeks prior to study enrollment * Malignancies other than UCB within 5 years prior to Cycle 1, Day 1, with the exception of those with low risk of metastasis or death treated with expected curative outcome (such as, but not limited to, adequately treated carcinoma in situ of the cervix, basal or squamous cell skin cancer, localized prostate cancer treated with curative intent and absence of PSA relapse, or ductal carcinoma in situ of the breast treated surgically with curative intent) or incidental prostate cancer (T1a, Gleason score ≤ 6 and PSA \< 0.5 ng/ml) * Prior immunotherapy with T-cell co-stimulation or checkpoint targeted agents (e.g., CTLA-4 inhibitors, anti-PD1 antibodies or anti-PD-L1 antibodies) * Intravesical chemotherapy or biologic therapy within 6 weeks of Cycle 1, Day 1 * Current participation in another clinical trial for MIBC * Nursing or pregnant woman * Uncontrolled cystitis, significant bladder pain or spasms, or gross hematuria that in the opinion of the principal investigator will preclude study participation * Major surgical procedures within 4 weeks of registration (other than for diagnosis) or anticipation that such a procedure will be needed during the study (other than RC)