Effects of Sevoflurane and Propofol on Optic Nerve Sheath Diameter During Laparoscopic Gynecologic Surgery

Early Phase 1UnknownNCT03498235

Obstetrics & Gynecology Hospital of Fudan University110 enrolled

Overview

Intracranial pressure（ICP) increases during laparoscopic gynecologic surgery increase (ICP) and may alter optic nerve sheath diameter(ONSD).This study measures ONSD in different team because sevoflurane and propofol have different effects on ICP.Half of participants will receive sevoflurane anesthesia,while the other half undergo propofol anesthesia.

Due to the anatomical and physiological characteristics of optic nerve sheath ,ONSD increases when ICP rises. Sevoflurane and propofol have different effects on ICP.When sevoflurane concentration \>1.1 minimum alveolar concentration（MAC),ICP increases because of cerebral vasodilatation；on the other hand ,propofol constricts the blood vessels and ICP decreases. ICP increases during laparoscopic gynecologic surgery because of steep Trendelenburg position and pneumoperitoneum . Meanwhile,sevoflurane affects self regulation of cerebral blood flow on the way of dose dependent,but propofol has no effects on self regulation of cerebral blood flow.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

110

Conditions

Laparoscopic Gynecologic Surgery

Interventions

SevofluraneDRUG

In Team Sevoflurane,patients undergo sevoflurane.

PropofolDRUG

In Team Propofol ,anesthesia is maintained with propofol

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society of Anesthesiologists physical status diagnosed as I or II Exclusion Criteria: * neuromuscular diseases;laboratory abnormalities in electrolytes; liver and kidney dysfunction;allergy to general anesthetics;pregnancy;ocular lesions including ocular trauma, optic neuritis, optic nerve tumor.

Locations (1)

Obstetrics & Gynecology Hospital of Fudan University

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Changes of ultrasonographic optic nerve sheath diameter

different time including pre-anesthesia, after intubation,every 15 minutes in the first hour after beginning of surgery, every hour when one hour after surgery beginning,surgery ending.