Prediction of Fluid Responsiveness From Passive Leg Raising Induced Changes in Perfusion Index and Pleth Variability Index

Institute of Mountain Emergency Medicine51 enrolled

Overview

The aim of the study is to evaluate whether changes in Perfusion Index (PI) and Pleth Variability Index (PVI) during passive leg raising test can predict fluid responsiveness in spontaneously breathing patients. Fluid responsive patients are defined as showing an increase in cardiac output \>10% during a passive leg raising test, measured semi-invaseively with FloTrac® (Edwards LifeSciences. Irvine, United States).

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Fluid Responsiveness

Interventions

Passive Leg Raising TestDIAGNOSTIC_TEST

A passive leg raising test is performed in all patients included in the study

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients admitted to the intensive or intermediate care unit after abdominal surgery (including urological and gynecological surgery performed in laparotomy) * Spontaneous breathing * Arterial line already in place * Oral and written informed consent obtained Exclusion Criteria: * Age \<18 years * Abdominal trauma as the reason for surgery * Missing informed consent

Locations (1)

"F. Tappeiner" Hospital Merano

Merano, Bolzano, Italy

Outcomes

Primary Outcomes

PI difference

Difference in the change of perfusion index from baseline during a passive leg raising maneuver in fluid responsive patients compared to fluid non-responders

Time frame: 90 seconds

PVI difference

Difference in the change of pleth variability index from baseline during a passive leg raising maneuver in fluid responsive patients compared to fluid non-responders

Time frame: 90 seconds

Data from ClinicalTrials.gov

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