Impact of Sleep Extension in Adolescents

N/AActive Not RecruitingNCT03500458

University of Colorado, Denver75 enrolled

Overview

Many teenagers do not get enough sleep. Obesity and diabetes are increasing in teenagers as well. This study plans to learn more about sleep and insulin resistance (insulin not working) in teenagers, and how these things may be related depending on sleep. This is important to know so that the investigators understand how sleep may play a role in health conditions like extra weight gain (increased food intake and less physical activity) and diabetes. To answer this question, the investigators plan to enroll teenagers who get \<7 hours of sleep on school nights and measure changes in insulin sensitivity and dietary intake after a week of typical sleep (sleeping on their normal school schedule) and a week of longer sleep (spending 1+ hour longer in bed each night).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Insulin Sensitivity Sleep Dietary Habits

Interventions

Eligibility

Sex: ALLMin age: 14 YearsMax age: 19 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. High school students between the age of 14-19 years 2. have typically insufficient sleep, defined by ≤ 7 hours per night on school days 3. BMI 5th-84th percentile for age and sex 4. habitually sedentary (\< 3 hours of regular physical activity per week) 5. Tanner stage 4 or 5, based on breast development for girls and testicular size for boys. Exclusion Criteria: 1. Any medications that affect IR or sleep (e.g., metformin, stimulants, atypical antipsychotics, current use of oral steroids) 2. regular use of melatonin or other sleep aids 3. a prior diagnosis of a sleep disorder (e.g. insomnia, delayed sleep phase syndrome, obstructive sleep apnea) 4. Type 2 diabetes or prediabetes 5. IQ\<70 or severe mental illness that may impact sleep or ability to consent/assent (e.g., schizophrenia, psychotic episodes) 6. teens not enrolled in a traditional high school academic program (e.g., home school students) 7. schedules that would preclude participants from adhering to the sleep manipulation (e.g. night shift employment) 8. travel across more than two time zones in the 2 weeks prior to the study.

Outcomes

Primary Outcomes

Change in Insulin Sensitivity

Insulin sensitivity assessed two times with an insulin-modified intravenous glucose tolerance test.

Time frame: 2 weeks after Baseline and 7 weeks after Baseline

Change in Sleep Duration & Timing

Assessed three times with a wrist-worn Actigraphy

Time frame: At Baseline, 1 week after Baseline, and 6 weeks after Baseline

Change in Physical activity

Assessed three times with a triaxial thigh-worn ActivPal

Time frame: At Baseline, 1 week after Baseline and 6 weeks after Baseline

Change in Dietary Intake

Participants will be asked to complete diet diaries two times for 3 days during each sleep condition (prior to each overnight assessment), listing all food and drink consumed, estimated portion size, and timing of consumption.

Time frame: 1 week after Baseline and 6 weeks after Baseline

Secondary Outcomes

Change in glycemic variability

Assessed two times with a continuous glucose monitor

Time frame: 2 weeks after Baseline and 7 weeks after Baseline

MTNR1B rs10830963 SNP

Genotyping will be conducted on saliva samples

Time frame: 2 weeks after Baseline