Combined Amniotic Membrane and Platelet Rich Plasma Clot for Management of Central Corneal Perforation

Minia University10 enrolled

Overview

Use of amniotic membrane(AMT) and platelet rich plasma (PRP) clot for closure of central corneal perforation

Use of amniotic membrane and platelet rich plasma clot for closure of central corneal perforation either post infective or posttraumatic

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Corneal Perforation

Interventions

Platelet rich plasma clot implantationPROCEDURE

Implantation of a platelet rich plasma clot, which is created from the plasma of the patients, and refrigerated to be inserted under the sealing amniotic membrane

Wound closure with amniotic membranePROCEDURE

Closure of the corneal perforation with a synthetic amniotic membrane with a 2 mm safety margin

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * central corneal perforation Exclusion Criteria: * active infection * posterior segment pathology * non seeing eye

Locations (1)

Faculty of Medicine

Minya, Egypt

Outcomes

Primary Outcomes

Closure of the corneal wound

sealing of the edges corneal gap, with formation of scar tissue

Time frame: 3 months

Data from ClinicalTrials.gov

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