This purpose of this study is to describe the effect of Tumor Treating Fields (NovoTTF) on quality of life (QOL), including exercise, sleep quality, and mood, in patients with World Health Organization (WHO) Grade IV malignant glioma who have been prescribed and approved to receive Optune™. This is an observational, longitudinal study, meaning that information about QOL will be collected over time while the patient is using the NovoTTF device (for example, Optune™).
Patients will be provided with a Fitbit Charge HR™, which they will begin wearing immediately to collect baseline information. The study team will teach the patients how to use the Fitbit and the associated smart phone application. Patients will also set an account with a platform that will provide information from the Fitbit (number of steps, sleep behaviors, and exercise log) to the study team. Patients will also have blood drawn, do a 6-minute walk test, and complete questionnaires at clinic visits 1, 8, 16, and 24 weeks after receiving the Fitbit. At the end of the study, patients will return the Fitbit to the study team.
Study Type
OBSERVATIONAL
Enrollment
20
We are studying the effect of Tumor Treating Fields (NovoTTF), for example Optune™, on the quality of life, including exercise, sleep quality, and mood, of patients with malignant glioma who plan to use the NovoTTF device.
The Preston Robert Tisch Brain Tumor Center at Duke
Durham, North Carolina, United States
Change in physical activity between baseline and week 24
Mean change between baseline and week 24 in total physical activity (MET-h/wk) as measured by the Godin Leisure Time Questionnaire
Time frame: Baseline, 24 weeks
Change in quality of life between baseline and week 24
Mean change from baseline at week 24 in subscales of the Functional Assessment of Cancer Therapy Brain (FACT-Br) and Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F)
Time frame: Baseline, 24 weeks
Change in sleep quality between baseline and week 24
Mean change from baseline at week 24 in sleep quality as measured by the Pittsburgh Sleep Quality Assessment (PSQI)
Time frame: Baseline, 24 weeks
Change in patient's mood state between baseline and week 24
Mean change from baseline at week 24 in mood as measured by the Beck Depression Inventory (BDI)
Time frame: Baseline, 24 weeks
Change in functional capacity between baseline and week 24
Mean change from baseline at week 24 in functional capacity as measured by the 6-minute walk test
Time frame: Baseline, 24 weeks
Change from baseline in average daily number of steps taken at 8, 16, and 24 (±3) weeks
Mean change from baseline at week 8, 16, and 24 in the average daily number of steps as measured by the Fitbit among patients treated with Novo TTF
Time frame: Baseline, 8, 16, 24 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.