The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
The purpose of this study is to determine the effects of 7 days of Nicotinamide Riboside (NR) or placebo supplementation on metabolism and vascular function following high-fat meal. Differences between young (18-35) and older (60-75) adults will be determined.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
16
250 mg capsules 2x/day for 7 days
2x/day for 7 days
Iowa State University
Ames, Iowa, United States
NAD+
Blood and peripheral blood mononuclear cell (PBMC) levels
Time frame: 7 days
Vasodilatory responsiveness
Post-Occlusion Reactive Hyperemia (PORH)
Time frame: 7 days
Lipdemia
Fasting and postprandial
Time frame: 7 days
Oxidative stress and inflammation
Plasma markers and expression in circulating PBMCs
Time frame: 7 days
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