Human Vasodilatory Effect of GLP-1

N/ACompletedNCT03502083

Papworth Hospital NHS Foundation Trust11 enrolled

Overview

Comprehensive assessment of human vasodilatory effect of GLP-1 in forearm and coronary arteries

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Coronary Stenosis Type2 Diabetes Angina, Stable

Interventions

GLP-1 (7-36)AmideDRUG

IV infusion

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Waiting list for elective PCI to LAD Able to give informed consent Over 18 Exclusion Criteria: * GLP-1 based therapy Insulin Calcium channel blockers Nicorandil Nitrates

Outcomes

Primary Outcomes

Change in IMR (index of microcirculatory resistance) with GLP-1 compared with baseline

Change in coronary microcirculatory resistance from baseline

Time frame: Change from baseline

Forearm bloodflow ratio with GLP-1

Peripheral vasodilatory response of GLP-1

Time frame: Change from baseline

Data from ClinicalTrials.gov

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