The good standard antibiotic prophylaxis pre elective C S is cefazolin and this study will approve addition of azithromycin to cefazolin will reduce post CS infections more than cefazolin only.
Patiants and methods Randomization: Patients fulfilling the inclusion criteria will be randomized to two groups. Both two group will receive standard prophylaxis antibiotic CEFAZOLIN (zinol) (at a dose of 1 g) 2 hours preoperative. Control Group: This group will include 200women undergoing elective cs. In this group, patients will receive standard antibiotic prophylaxis CEFAZOLIN (at a dose of 1 g) and azithromycin (at a dose of 1g) 2 hours preoperative. Study Group: This group will include 200women undergoing elective cs. In this group, patients will receive only standard prophylaxis antibiotic(CEFAZOLIN) Inclusion criteria: * Gestational age of 37 0/7 weeks and greater * Elective cesarean section * Medicaly free pregnant women Exclusion criteria: * a known allergy to azithromycin * obstetric complications * azithromycin use within 7 days before randomization * chorioamnionitis or other infection requiring postpartum antibiotic therapy * Pre-gestational diabetes
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
400
In this group, patients will receive standard antibiotic prophylaxis CEFAZOLIN (at a dose of 1 g) and azithromycin (at a dose of 1g) 2 hours preoperative.
Ain Shams
Cairo, Elabasy, Egypt
RECRUITINGendometritis
Endometritis was defined as the presence of at least two of the following signs with no other recognized cause: fever (temperature of at least 38°C \[100.4°F\]), abdominal pain, uterine tenderness, or purulent drainage from the uterus
Time frame: 6 weeks after surgery
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