Synaptic Plasticity and Cognitive Function in RASopathies

Inclusion Criteria: 1. Group 1: NS, Group 2: NF1 (both genetically assured) 2. Age ≥16 years 3. The adolescent (≥16) and legal guardian who are capable to give their consent and understand the aim and rationale of the study. In case of doubts, an independent medical practitioner will evaluate the capacity to consent. 4. Signed informed consent if ≥ 16 years and legal guardian. 5. Persons who are ≥ 18 years old and capable to give their consent and understand the aim and rationale of the study. In case of doubts, an independent medical practitioner will evaluate the capacity to consent. 6. Signed informed consent if ≥ 18 years. 7. Male participants and female participants who are not capable of bearing children or who use a method of contraception that is medically approved by the health authority of the respective country. Exclusion Criteria: 1. Epilepsy 2. Medication with known CNS effects 3. Severe mental retardation 4. Side effects during previous medication with and contraindications for LTG and/or LOV and/or TMS 5. Psychiatric diseases 6. Previous history of allergic reactions with LTG and LOV medications 7. Potentially unreliable patients 8. Patients who are not suitable for the study in the opinion of the investigator 9. Pregnancy (incl. positive urine pregnancy test) 10. Persons who are incapable of giving consent or do not understand the aim or rationale of the study.