Adipokines Effect in Myometrial Contractility

University of Minnesota60 enrolled

Overview

Investigate the effect of two adipokines which are adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery

Study Type

OBSERVATIONAL

Enrollment

Conditions

Myometrium; Contractility GDM Obesity

Interventions

Adiponectin and TNFaBIOLOGICAL

Adiponectin and TNFa are adipokines. Will be added to the myometrial biopsies to investigate their effect on the force of contractility

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant patients scheduled for a CS at 37-41 weeks of gestation at M Health Birth Place * Participants age ≥18. * Full informed consent able to be provided by the participant. Exclusion Criteria: * Patients undergoing general anesthesia for their CS. * Pre-gestational DM, and DM diagnosed \<24 weeks gestation. * Patients unable to consent for themselves * Multiple gestation

Locations (1)

Fairview Hospital

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Effect on force of contractility

Determine the effect of adiponectin and TNFa on the force of myometrial contractility in diabetic, non-obese pregnant women and obese, non-diabetic term pregnant women at the time of scheduled cesarean delivery

Time frame: 24 hours

Secondary Outcomes

Force of contractility between study groups

Compare the force of myometrial contractility in study groups compared to control group (non-DM, non-obese term pregnant patients)

Time frame: 24 hours

Progesterone effect in control group

Investigate the anti-inflammatory properties of Progesterone (P4) and 17a-Hydroxyprogesterone (HPC) on Adiponectin induced myometrial contractility in control group

Time frame: 24 hours

Data from ClinicalTrials.gov

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