Effect of Oral Collagen Tripeptide on Skin Moisture and Wrinkles in Adult Women

Pusan National University Yangsan Hospital84 enrolled

Overview

Comparison of a randomized, double-blind, and control-group study for the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants

The aim is to investigate the effect of oral ingestion of collagen tripeptides derived from fish on dermal moistures and wrinkles body fat reduction in participants by a randomized, double-blind, and control-group study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Skin Manifestations Skin Wrinkling

Interventions

CTPDIETARY_SUPPLEMENT

1,000 mg of CTP was orally administered per day for 12 weeks.

placebo (starch)DIETARY_SUPPLEMENT

placebo (starch)

Eligibility

Sex: FEMALEMin age: 40 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- \> = 4 of Tewameter Exclusion Criteria: * Within the last 6 months, took skin surgery including cosmetic purpose * Diabetic patients with poor glycemic control with a fasting blood glucose of 160 mg/dl or more * Creatinine levels: more than twice the normal upper limit * AST (GOT) or ALT (GPT) levels: more than twice the normal upper limit * Uncontrolled hypertension * sun allergy or sensitive skin * functional cosmetics that affect dermal moistures and wrinkles within the last 3 months. * If you have participated or are planning to participate in another clinical trial within the past month * Alcohol abuser * If they are pregnant or lactating or have a pregnancy plan during the clinical trial Those with allergic reactions to the constituent food * Any person deemed inappropriate by the researcher for other reasons

Locations (1)

Integrated Research Institute for Natural Ingredients and Functional Foods

Yangsan, South Korea

Outcomes

Primary Outcomes

changes in Transepidermal Waterloss by Tewameter

comparison between baseline, after 6 weeks, and after 12 weeks

Time frame: baseline, after 6 weeks, and after 12 weeks

Secondary Outcomes

changes in skin wrinkling indices by Visiometer

comparison between baseline, after 6 weeks, and after 12 weeks

Time frame: baseline, after 6 weeks, and after 12 weeks

skin elasticity by Cutometer

comparison between baseline, after 6 weeks, and after 12 weeks

Time frame: baseline, after 6 weeks, and after 12 weeks

changes in hydration level of the skin surface by Corneometer

comparison between baseline, after 6 weeks, and after 12 weeks

Time frame: baseline, after 6 weeks, and after 12 weeks

Data from ClinicalTrials.gov

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