Pneumonia Due to Stenotrophomonas Maltophilia in ICUs

Groupe Hospitalier Pitie-Salpetriere300 enrolled

Overview

Pneumonia is a major cause of ICU admission, or may complicate ICU course. Among the causative pathogens, Stenotrophomonas Maltophilia is a rare pathogen, but affects usually patients with chronic pulmonary co-morbidities, or with long duration of mechanical ventilation and multiples treatment with broad spectrum antimicrobial therapy. However, there are only a paucity of data regarding epidemiology, impact and outcome of Pneumonia due to Stenotrophomonas Maltophilia in critically ill patients. Primary objective was to study factors associated with mortality in case of Pneumonia due to Stenotrophomonas Maltophilia. Secondary objectives were to describe factors associated with morbidity of Pneumonia due to Stenotrophomonas Maltophilia (duration of mechanical ventilation, ICU length of stay), and to report the characteristics of critically ill patients presenting Pneumonia due to Stenotrophomonas Maltophilia.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Pneumonia, Ventilator-Associated Stenotrophomonas Infection Critical Illness Pneumonia, Bacterial

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Patients older than 18 years Documented Stenotrophomonas maltophilia pneumonia: * Clinical suspicion (≥ two criteria including: fever\> 38.5°C, leukocytosis \> 10\^9/L or leukopenia \< 4.10\^8/L, purulent tracheobronchial secretions and a new or persistent infiltrate on chest radiography). * Documented Stenotrophomonas maltophilia positive quantitative culture of a respiratory sample: bronchoalveolar lavage fluid (significant threshold, \>10\^4cfu/ml) or plugged telescopic catheter (significant threshold, \>10\^3cfu/ml) or quantitative endotracheal aspirate (significant threshold, \>10\^6cfu/ml). Exclusion Criteria: * None

Locations (4)

Réanimation Polyvalente CHR Metz-Thionville

Metz, France

Department of Anesthesiology and Critical Care Medicine, University Hospital of NANCY

Nancy, France

Department of Anesthesiology and Critical Care Medicine, University Hospital of Strasbourg

Strasbourg, France

Anesthesiology and Critical Care Medicine, Groupe Hospitalier Pitié-Salpêtrière

Paris, Île-de-France Region, France

Outcomes

Primary Outcomes

Treatment failure

Treatment failure is defined as composite of death and recurrence of pneumonia due to Stenotrophomonas Maltophilia within 30 days of the first episode

Time frame: Day 30

Secondary Outcomes

Duration of mechanical ventilation

Number of days under mechanical ventilation

Time frame: Day 30

Recurrence of pneumonia due to Stenotrophomonas Maltophilia

New onset of pneumonia due to Stenotrophomonas Maltophilia

Time frame: Day 30

Mortality

Time frame: Day 30