The present study will investigate variations in acid base equilibrium caused by the administration of four different crystalloids with increasing strong ion difference (0.9% saline, Ringer's lactate, Ringer's acetate, plasmalyte-like solution) in patients during general anesthesia. The same crystalloid will be administered throughout the surgery. In order to assess the effect of hemodilution, every patient will receive two fluid boli with different volumes of the same solution. pH and strong ion variations, togher with the renal response to acid base disturbances, will be analysed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
45
Each patient will receive 0.9%saline based on attending physician decision
Each patient will receive Ringer's lactate based on attending physician decision
Each patient will receive Plasmalyte-like solution based on attending physician decision
Fondazione Policlinico A. Gemelli
Roma, Italy
pH modification
The primary outcome of this physiological study is to evaluate, in vivo, the effect of crystalloid administration with different SID on acid base equilibrium, in particular pH variations will be considered.
Time frame: Surgery
Urinary SID modification (mEq/L) after crystalloids administration with different SID and chloride load
renal response to acid base disturbances caused by different crystalloid infusions and different volumes.
Time frame: Surgery
SID and plasmatic weak acid (A tot) variations measured in mEq/L
We will explore the changes in apparent SID (SIDapp) and effective SID (SIDeff) and strong ion gap (SIG), as well as A tot after administration of solutions with different SID
Time frame: Surgery
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