The objective of this study is to evaluate the long-term efficacy and safety of coronary stenting with the various types of drug-eluting stents (DES) and to determine clinical device and procedural success during commercial use of DES in the real world. The investigators will compare EES (Xience V/Promus and Xience Prime), SES (Cypher), ZES (Resolute Integrity, Endeavor Resolute, Endeavor), and BES (Biomatrix, Biomatrix Flex, and Nobori).
The Grand Drug-Eluting Stent (Grand-DES) Registry incorporated five different multicenter registries in South Korea. The EXCELLENT prospective cohort and the EXCELLENT-PRIME registry were dedicated for durable polymer-coated everolimus-eluting stents (DP-EES; Xience V/Promus and Xience Prime) or 1st-generation sirolimus-eluting stents (Cypher), the HOST-RESOLINTE and RESOLUTE-Korea registry for durable polymer-coated zotarolimus-eluting stents (DP-ZES; Resolute Integrity and Endeavor Resolute) or 1st-generation Endeavor-ZES, and the HOST-BIOLIMUS-3000-Korea registry for biodegradable polymer-coated biolimus-eluting stents (BP-BES; Biomatrix, Biomatrix Flex, and Nobori). During the period of 2008 through 2014, all registries enrolled all-comers without any exclusion criteria except patient's withdrawal of consent.
Study Type
OBSERVATIONAL
Enrollment
17,286
Biodegradable polymer-coated biolimus-eluting stents
Durable polymer-coated everolimus-eluting stents
Durable polymer-coated everolimus-eluting stents; Sirolimus-eluting stents
Target lesion failure
A composite of cardiac death, target-vessel myocardial infarction, and clinically-driven target lesion revascularization
Time frame: 36 months
Patient-oriented composite outcome
A composite of all-cause death, all-cause myocardial infarction, and any repeat revascularization
Time frame: 36 months
All-cause death
All-cause death
Time frame: 36 months
Cardiac death
Cardiac death
Time frame: 36 months
All-cause myocardial infarction
All-cause myocardial infarction
Time frame: 36 months
Target-vessel myocardial infarction
Target-vessel myocardial infarction
Time frame: 36 months
Any repeat revascularization
Any repeat revascularization
Time frame: 36 months
Clinically-driven target vessel revascularization
Clinically-driven target vessel revascularization
Time frame: 36 months
Clinically-driven target lesion revascularization
Clinically-driven target lesion revascularization
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Durable polymer-coated zotarolimus-eluting stents
Durable polymer-coated zotarolimus-eluting stents
Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea
Sejong General Hospital
Bucheon-si, Gyeonggi-do, South Korea
Seoul National University Hospital
Seoul, Jongno-gu, South Korea
Hallym University Sacred Heart Hospital
Anyang, South Korea
Kosin University Gospel Hospital
Busan, South Korea
Dankook University Hospital
Cheonan, South Korea
Soon Chun Hyang University Hospital Cheonan
Cheonan, South Korea
Chungnam National University Hospital
Daejeon, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Gwangju Christian Hospital
Gwangju, South Korea
...and 27 more locations
Time frame: 36 months
Definite or probable stent thrombosis
Definite or probable stent thrombosis
Time frame: 36 months