Retrobulbar Block Versus Ketamine Infusion for Post-enucleation Analgesia

Nazmy Edward Seif45 enrolled

Overview

This study compares the efficacy and safety of two techniques, retrobulbar block versus intra-operative ketamine infusion, for control of post-operative pain occurring in patients undergoing ocular enucleation or evisceration performed under general anesthesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Enucleated; Eye Evisceration; Operation Wound Pain, Postoperative

Interventions

Retrobulbar blockPROCEDURE

Patients will receive a single retrobulbar injection with 3-4ml of an equal mixture of Lidocaine 2% \& Bupivacaine 0.5% + Hyaluronidase (10 IU/ml), after induction of general anesthesia.

KetaminePROCEDURE

Patients will receive a 0.5 mg/kg bolus followed by an infusion of 0.25 mg/kg/h of intravenous Ketamine, after induction of general anesthesia.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ocular enucleation candidate patients * Ocular evisceration candidate patients Exclusion Criteria: * Any condition contra-indicating general or local anesthesia * Allergy to any of the drugs used during the procedure

Locations (1)

Kasr Al-Ainy Hospital, Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Time to the first post-operative rescue analgesia.

Time (measured in minutes) elapsed till the patient requires to receive his first post-operative rescue analgesic dose.

Time frame: 24 hours

Data from ClinicalTrials.gov

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