This is a single dose (SD), non-randomized, open-label, adaptive, parallel group study with the purpose of investigating the occupancy of alpha5-containing GABAA receptors by RO7017773 in healthy participants.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
6
RO7017773 will be administered orally. The doses to be tested will be determined by review of PET scan, PK, and safety results from the previous dose level.
At the start of each PET scan, participants will receive an intravenous dose of the radiolabeled tracer \[11C\]Ro15-4513.
Hammersmith Medicines Research; Central Middlesex Hospital
London, United Kingdom
Percentage of Brain Alpha5-Containing GABA-A Receptors Occupied by RO7017773
Time frame: Baseline up to 48 hours (hrs)
Plasma Concentrations of RO7017773
Time frame: Baseline up to 48 hrs
Number of Participants With Adverse Events (AEs)
Time frame: From treatment initiation until 14 days after the last dose of study treatment.
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