Anti-infectious Therapy of Periodontitis - Comparison of Different Clinical Strategies

RWTH Aachen University228 enrolled

Overview

It is the aim of the study to evaluate the efficiency of "One stage full mouth disinfection" according to the original protocol (Quirynen et al. 1995) in comparison to other approaches considering different scaling strategies and different disinfection concepts. Therefore, a multicenter randomized control treatment will be performed. In total, 204 patients with chronic periodontitis shall be allocated to the following treatment concepts. Group A: quadrant scaling with weekly intervals (Q-SRP; N = 51); Group B: full mouth scaling (FMS; N = 51); Group C: full mouth disinfection (FMD; N = 51); Group D: full mouth disinfection with subgingival glycine air polishing using erythritol powder (FMDP; N = 51). Evaluation of periodontopathic parameters and periodontal pathogens at baseline, 3 months and 6 months shall give evidence about the benefits of concept and the single components of FMD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

228

Conditions

Periodontitis

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with generalized moderate to severe chronic periodontitis * presence of at least 18 teeth * with at least 2 multi-rooted and / or 2 single-rooted teeth in the first quadrant with at least 6 sites with periodontal probing depth of ≥ 6 mm * radiographic bone loss of at least 25% of the root length Exclusion Criteria: * subgingival scaling and root planing within the last 12 months * antimicrobial rinsing or intake of systemic antibiotics within the last 4 months * systemic diseases with known interactions to periodontal disease or known need for antibiotic prophylaxis * known intolerance / allergies to chlorhexidine * pregnancy

Locations (5)

Universitätsklinikum RWTH Aachen, Klinik für Zahnerhaltung, Parodontologie u. Präventive Zahnheilkunde

Aachen, Germany

Charité Centrum Zahn-, Mund- und Kieferheilkunde, Parodontologie und Synoptische Zahnmedizin

Berlin, Germany

Universitätspoliklinik für Zahnerhaltungskunde und Parodontologie

Halle, Germany

Universitätsmedizin Mainz, Poliklinik f. Zahnerhaltung u. Parodontologie

Mainz, Germany

Department of Dental Medicine 1 (Periodontology)

Timișoara, Romania

Outcomes

Primary Outcomes

Change of clinical attachment level

Measuring the change of the distance between the cemento-enamel junction and the bottom of the periodontal pocket 3 and 6 months after therapy compared to baseline