Treatment of Disruptive Behaviors in Fragile X Syndrome

Inclusion Criteria: 1. Child has a confirmed diagnosis of FXS (\>200 CGG repeats on the FMR1 gene with evidence of aberrant methylation) 2. Child is male, between the ages of 3-10 years old 3. Child is reported to show self-injury, property destruction and/or aggression on at least a daily basis 4. The caregiver agrees to keep any therapies that the child receives (i.e., medications or other treatments) as stable as possible throughout involvement in the study 5. The family has a high-speed internet connection at home or lives in an area with 4G network coverage 6. Availability for one-hour daily telemedicine treatment sessions 7. Availability for in-home assessment totaling 8 hours across two consecutive days Exclusion Criteria: 1. The child or caregiver has significant sensory impairments (e.g., blindness or deafness) 2. Non-English speaking 3. The child receives Applied Behavior Analysis services in excess of five hours per week 4. The child has a significant neurological condition (e.g., frequent seizures, brain injury, Tourette's syndrome) that would preclude participation 5. The child or caregiver has significant mobility issues 6. The child is currently participating in another research study that would preclude participation in the study