This study aims to determine if the addition of Sodium Benzoate and / or NAC to TAU will be acceptable and tolerable and result in overall improvement of symptoms, social and cognitive functioning in patients with early schizophrenia spectrum disorder.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
64
Sodium Benzoate will be administered at 1000mg daily
N-Acetylcysteine 1000 mgs twice daily dose
Placebo added to TAU
Balochistan Institute of Behavioral Science
Quetta, Balochistan, Pakistan
Institute of Psychiatry, Rawalpindi
Rawalpindi, Islamabad, Pakistan
Abbasi Shaheed Hsopital
Karachi, Sindh, Pakistan
Civil Hospital Karachi
Karachi, Sindh, Pakistan
Feasibility of intervention ( including recruitment rates and drop outs)
Feasibility estimates of delivering the intervention including recruitment rates and drop outs
Time frame: Recruitment within 12 months of study start start date
Overall improvement in symptoms using the Positive and Negative Syndrome Scale (PANSS) total score
The PANSS is measured on a 7-point scale, and is a 30-item structured clinical interview assessing symptom severity over the previous week. The PANSS scale has a maximum score of 210 and a minimum of 30. Higher scores indicate higher severity of illness.
Time frame: change in scores from Baseline to 12 weeks
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Sodium Benzoate will be administered at 1000mg daily and NAC 1000 mgs twice daily dose
Karwan e Hayat
Karachi, Sindh, Pakistan