To study the pharmacokinetic characteristics of TQ-B3525 in the human body, recommend a reasonable regimen for subsequent research.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
60
TQ-B3525 p.o. qd
People's Hospital of Tianjin
Tianjin, Tianjin Municipality, China
RECRUITINGDose-Limiting Toxicities (DLT)
DLT: An adverse event occurring after initiation of TQ-B3525 that met any following criteria: 1. \>=Grade 3 of non-hematology toxicity 2. Grade 4 hematology toxicity
Time frame: Baseline up to 28 days
Maximum Tolerated Dose (MTD)
MTD was defined as the highest dose level studied for which the incidence of first cycle DLT was \< 33%.
Time frame: Baseline up to 28 days
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