Optimization of HIV-1 DNA Genotyping by High Throughput Sequencing to Document Antiretroviral Resistant Mutations

Inclusion Criteria: * Patient who has given consent * Adult patient * Patient living with HIV-1 * Controlled viral load (\<50 RNA copies/ml) for at least 1 year. * At least two previous virologic failures, either : * Initial failure : defined as the persistence of a viral load greater than 50 copies/ml beyond 1 year, after the initiation of triple antiretroviral therapy, and without virological control (VL \> 50 copies/ml) since the initiation of the very first antiretroviral treatment. * A rebound in HIV viral load to more than 50 copies/ml after a period of virological success, confirmed on two consecutive samples at least one month apart. * At least 2 Sanger RNA genotypes have been done or could be done from the existing library. Exclusion Criteria: * Patient not affiliated to a medical insurance scheme * Protected adult * Pregnant, parturient or breastfeeding woman * Discontinuation of clinical and immuno-virological follow-up for more than 2 years