Comparison of Reversal of Neuromuscular Blockade With Sugammadex Versus Neostigmine Plus Glycopyrolate in Patients Undergoing Burn Surgery

University of Kansas Medical Center7 enrolled

Overview

The purpose of this study is to learn if there is a difference in recovery time when using sugammadex versus neostigmine. The researchers also hope to add further knowledge and data to the safety of using sugammadex in burn patients who are hypermetabolic.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Burns

Interventions

SugammadexDRUG

Sugammadex is indicated for the reversal of neuromuscular blockade.

NeostigmineDRUG

Neostigmine is indicated for the reversal of neuromuscular blockade.

GlycopyrrolateDRUG

Glycopyrrolate is used in conjunction with neostigmine to prevent neostigmine's muscarinic effects.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Undergoing burn surgery under general anesthesia Exclusion Criteria: * Patients without a non-burned upper extremity * Renal insufficiency or failure * Sensitivity or hypersensitivity reaction to sugammadex * Liver impairment, neuromuscular degenerative disease or dependence on drugs or alcohol

Locations (1)

University of Kansas Medical Center

Kansas City, Kansas, United States

Outcomes

Primary Outcomes

Time to return to a 90% Train of Four (TOF) neuromuscular twitch

Time frame: Within 24 hours after surgery

Secondary Outcomes

Time to endotracheal extubation

Time frame: Within 24 hours after surgery

Time to discharge from the operating room

Time frame: Within 24 hours after surgery

Data from ClinicalTrials.gov

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