Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact.

Universidade do Porto30 enrolled

Overview

Our aim is to assess the effects of moderate consumption of beer and non-alcoholic beer on gut microbiota and biochemical biomarkers in healthy adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

Conditions

Healthy Volunteers

Interventions

Beer with 5.20 % alcoholDIETARY_SUPPLEMENT

330 ml beer (5.20 % alcohol)/day during 4 weeks

Non-alcoholic beer with 0.45 % alcoholDIETARY_SUPPLEMENT

330 ml non-alcoholic beer (0.45 % alcohol)/day during 4 weeks

Non-alcoholic beer with 0.00 % alcoholDIETARY_SUPPLEMENT

330 ml nonalcoholic beer (0.00 % alcohol)/day during 4 weeks

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Adult men (18-65 years); * Healthy volunteers free of chronic diseases with relevant effect on gastrointestinal system; * Without a diagnosis of any digestive disease including functional bowel disorders such as IBS; * Moderate alcohol consumers; * Willing and able to provide written informed consent. Exclusion Criteria: * Documented cardiovascular disease (ischaemic heart disease - angina or recent or old myocardial infarction or previous or cerebral vascular accident, peripheral vascular disease); * With diabetes or other relevant metabolic diseases; * With any known infectious diseases, namely infections with HIV, Hepatitis B or C virus; * Intake of antibiotics in the last 4 weeks and laxatives in the last 2 weeks; * Subjects with history of drug, alcohol or other substances abuse.

Locations (1)

Faculdade de Ciências Médicas da Universidade NOVA de Lisboa

Lisbon, Portugal