Risk Factors of Meconium Obstruction and Respiratory Distress Syndrome in Preterm Infants

Seoul National University Hospital48 enrolled

Overview

Although the pathophysiology of meconium obstruction of prematurity (MOP) is not clear, it is known that the decrease of the intestinal peristalsis due to decreased intestinal perfusion during antenatal or perinatal period. Recently, the level of citrulline has been used as an index of function and injury of the small intestine State. This study aimed to evaluate citrulline level of cord blood as a marker for early detection and observe changes in intestinal blood flow in MOP patient. And We aimed to confirm the efficacy of the AT/ET ratio (ratio of the pulmonary artery time-to-peak velocity interval to the right ventricular ejection time) of the prenatal pulmonary artery as a noninvasive predictor of neonatal respiratory distress syndrome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Meconium Obstruction of Prematurity Respiratory Distress Syndrome in Premature Infant

Eligibility

Sex: ALLMax age: 34 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * premature infants born less than 34 weeks from mother with pregnancy induced hypertension, pre-eclampsia or eclampsia Exclusion Criteria: * major congenital anomalies * infants with hypotension while using inotropics

Locations (1)

Outcomes

Primary Outcomes

Comparison of citrulline level between the meconium obstruction group and the normal feeding advance group

check the citrulline llevel from blood at birth

Time frame: within 6 hours after birth

Comparison of prenatal AT/ET ratio of fetal pulmonary artery between respiratory distress syndrome group and the normal respiration group

Check the AT/ET ratio of fetal pulmonary artery within 10 days before birth

Time frame: within 10 days before delivery