The purpose of this study is to develop simple diagnostic screeningtests and investigate potential biomarkers for identifying patients with abnormalities of mitochondrial function, which also can be used as outcome measures in future clinical trials. The study will investigate two submaximal tests: a submaximal handgrip test and a walking test. Furthermore investigators will investigate Acyl-carnitine profiles and GDF-15 levels in patients with mitochondrial myopathy.
Study Type
OBSERVATIONAL
Enrollment
50
Handgrip test, 12-minute walk test and 6-minute walk test. Biomarkers: acyl-carnitine profile and GDF-15.
Copenhagen Neuromuscular Center, Rigshospitalet
Copenhagen, Denmark
Serum lactate / pyruvate ratio
Changes between: before, during and after submaximal exercise
Time frame: 1 hour
Serum Acyl-carnitine levels
Changes between: before and after exercise, fasted and fed.
Time frame: 1 hour
Serum GDF-15
Changes between: before and after exercise, fasted and fed.
Time frame: 1 hour
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.