Safety and Tolerability of LEO 138559 in Healthy Subjects and Subjects With Atopic Dermatitis

Inclusion Criteria: For healthy subjects and subjects with atopic dermatitis: * Males and females without childbearing potential. * Age between 18 and 55, inclusive. * Body mass index between 18 and 32 kg/m2, inclusive. * Healthy apart from atopic dermatitis for the subjects presenting the disease. For subjects with atopic dermatitis only: * History of atopic dermatitis for more than 6 months. * Female subjects with childbearing potential and male subjects with female partners with childbearing potential using highly effective contraception from start of the trial and until a period after the last administered dose of trial drug. Exclusion Criteria: For healthy subjects and subjects with atopic dermatitis: * Any significant disease detected prior to enrolment. * Subjects who are still participating in a clinical trial or who have participated in a clinical trial within 3 months prior to enrolment or within 5 times of the half-life of the experimental therapy, whichever is longer. * Skin diseases that may interfere with the diagnosis of atopic dermatitis or assessment of the treatment. * Use of tanning beds or phototherapy within 6 weeks prior to enrolment. * Subjects with atopic dermatitis requiring more than 3 bleach baths from 4 weeks prior to screening until end of trial. * Blood pressure or pulse rate outside of the normal range. For subjects with atopic dermatitis only: * Initiation of treatment of atopic dermatitis with prescription emollients during the screening period.