The aim of the study is a comparative study of the cellular immunity response of patients operated on for kidney cancer under total intravenous and inhalational anesthesia.
The severity of perioperative immunosuppression is directly proportional to the degree of surgical stress. A series of experimental and clinical studies indicate a different effect of certain types of anesthesia on immunity. It is believed that surgical stress itself opens an opportunity for the recurrence of oncological diseases precisely due to the immunosuppressive effect. The aim of present pilot clinical study is to test a hypothesis that total intravenous anesthesia as superior to inhalational anesthesia in term of its effects on cell immunity among patients with kidney cancer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Propofol will be used for anesthesia during surgery
Sevoflurane will be used for anesthesia during surgery
Epidural catheterization Th9-Th10, ropivacaine for perioperative analgesia
State Research Institute of Circulation Pathology
Novosibirsk, Russia
CD 16
NK cells expression of CD16 receptor
Time frame: postoperative day 1
CD45
CD45 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD3
CD3 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD19
CD19 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD4
CD4 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD8
CD8 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD16
CD16 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
CD25
CD25 expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7
HLA-DR
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HLA-DR expression on lymphocytes measured with flow cytometry
Time frame: Baseline, end of surgery, postoperative days 1, 3-4, 7