Respiratory Muscle Contribution to Blood Pressure During Exercise

Mayo Clinic38 enrolled

Overview

The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle training) influences the respiratory muscle contribution to blood pressure during exercise.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Respiratory Muscle Blood Pressure Exercise Capacity Sympathetic Nerve Activity

Interventions

Inspiratory Muscle Training (IMT)OTHER

Inspiratory muscle training (IMT) are breathing exercises used to increase strength and endurance of the respiratory muscles.

No Inspiratory Muscle Training (IMT)OTHER

No inspiratory muscle training.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Healthy participants with no history of cardiovascular, pulmonary, neurologic, orthopedic or other neuromuscular diseases.

Locations (1)

Mayo Clinic

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

VO2 max test

Using a MedGraphics metabolic cart, the investigators will measure the maximum amount of oxygen that an individual can utilize during exercise. During this test the subject will be asked to exercise to his/her max capacity on a recumbent bicycle while breathing through a mouth piece that is hooked into the MedGraphics computer software.

Time frame: Through study completion, an average of one year.

Blood Pressure

Blood pressure will be taken every few minutes during exercise testing using a standard blood pressure cuff to monitor changes in blood pressure.

Time frame: Through study completion, an average of one year.

Data from ClinicalTrials.gov

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