Study on Prevention and Treatment of Dry Eye in Patients Using Glaucoma Drops

Inclusion Criteria: * 18-80 years of age, diagnosed with glaucoma, including primary open-angle glaucoma or primary angle closure glaucoma, require treatment with anti-glaucoma eye drops. * A group: Patients using glaucoma eye drops longer than 6 months, and in accordance with the diagnostic criteria of dry eye: 1. Subjective symptoms (required): dryness, foreign body sensation, fatigue and discomfort; 2. The instability of tear film (required): tear break up time (TBUT); 3. Lacrimal secretion: Schirmer I test; 4. The ocular surface damage (strengthen diagnosis): fluorescein staining (FL); in the mentioned in ①+②（TBUT≤5s) or ①+②（TBUT≤10s)+③（\<10mm）/④（FL+）。 * The choice of study eyes: Choose the eye of the patient with low basical intraocular pressure, and if the basal intraocular pressure is the same, choose the right eye for the study. * Voluntary participation in this clinical study, and signed informed consent. Exclusion Criteria: * With metabolic diseases, autoimmune diseases, connective tissue diseases, such as diabetes, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Sjogren's syndrome eat; * Combined with cerebrovascular, liver, kidney, hematopoietic serious system desease, atumor diseases and psychosis. * Using any artificial tears and except any clinical trials of dry eyes within two weeks. * With drug therapy, embolization and surgical treatment of dry eyes. * With other eye diseases, such as eyelid defects, hypophasis, pterygium, chronic dacryocystitis, trichiasis, corneal lesions.