Prospective and randomized compare between microsurgical and endoscopic transsphenoidal MRI assisted resection of pituitary adenomas.
The main aim of the study is to compare microsurgical and endoscopic transsphenoidal surgery and to determine endocrine outcome. Secondary extent of resection and quality of life will be evaluated.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
36
Transsphenoidal endoscopic resection of pituitary adenoma
Transsphenoidal microsurgical resection of pituitary adenoma
Department of Neurosurgery
Günzburg, Germany
endocrine function
Testing of pituitary function with insulin-hypoglycemic test, results will be dichotomized as satisfactory or not satisfactory. Satisfactory outcome is defined, if pituitary function improves or is stable, if compared to preoperative testing.
Time frame: 1 year after surgery
Extent of resection
Volumetric analysis of tumor volume before the surgery, intraoperatively and 3 months after surgery will be performed. Gross total resection is defined as no tumor present in gadolinium enhanced T1 sequences
Time frame: tumor volume before the surgery, 3 months after surgery
Quality of Life, EQ-5D
EQ-5D will be evaluated before surgery, after the surgery in 3 months and after 1 year.
Time frame: 3 months and 1 year after surgery
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