This project offers the opportunity to obtain detailed measurements on the health of body composition, metabolic health, and intestinal microbial diversity in overweight adults; moreover to provide information about the effects of physical exercise on them. The aim of the research is to advance in the understanding of the mechanisms induced by physical exercise, which includes the measurement of nutritional parameters, clinical and biochemical biomarkers of hepatic/cardiometabolic health, as well as the application of differential proteomics technologies by means of Arrays of cytokines and intestinal microbiome, making this study a novel and pioneer in sensitive areas of primary health care in Latin America.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Physical Training
Robinson Ramírez-Vélez
Bogotá, Cundinamarca, Colombia
Gut microbiota
Change from Baseline in the gut microbiota composition measured by amplicon sequencing
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma metabolomic profile
Change from Baseline in the metabolomic profile will be also evaluated by a HPLC-MS approach
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Chemerin will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Selenoprotein P will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the Fetuin-A will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Plasma hepatokines
Change from Baseline in the FGF21 (fibroblast growth factor 21) Leukocyte cell-derived will be measured using ELISA kits
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Glucose
Change from Baseline will be also evaluated by a spectroscopy
Time frame: Baseline, and 6 weeks immediately after the interventions ends
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Insulin
Change from Baseline will be also evaluated by a ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Glycated hemoglobin
Change from Baseline will be also evaluated by a ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma IL-1 concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma IL6 concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma TNF-alfa concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Bioinflammatory blood markers
Change from Baseline measure of plasma CRP concentrations measured ELISA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in body weight (kilograms) measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in body fat (%) measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Body composition
Differences in mass muscle measured by DXA
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Physical fitness
Differences in Muscular strength (handgrip test) in kg
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Physical fitness
Differences in Maximum Oxygen Consumption (VO2 max K5 Gas Analyser) in ml/kg/min
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Energy substrate oxidation
Fat and carbohydrate oxidation in the fasted and postprandial state measured before and after the interventions using indirect calorimetry (K5 cosmed)
Time frame: Baseline, and 6 weeks immediately after the interventions ends
Resting Metabolic Rate
Resting metabolic rate was measured before and after the interventions (K5 Cosmed)
Time frame: Baseline, and 6 weeks immediately after the interventions ends