Matrix Metalloproteinases's in Oral Biofluids During Pregnancy and Postpartum

Aydin Adnan Menderes University114 enrolled

Overview

The aim of this study was to investigate salivary and gingival crevicular fluid (GCF) levels of MMP-8, MMP-9 and TIMP-1 during 2/3 trimester of pregnancy and after delivery

MMP-8 and MMP-9 have been reported to reflect the inflammatory status in periodontal tissues and, therefore represent as potential biomarkers of periodontitis. The balance between tissue inhibitors of metalloproteinases (TIMPs) and MMPs play an important role in maintaining the integrity of healthy periodontium.

Study Type

OBSERVATIONAL

Enrollment

114

Conditions

Pregnancy

Interventions

Saliva collectionOTHER

GCF collectionOTHER

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant group included women, who were in their second trimester (weeks 16-24) and third trimester (weeks 25-34) Exclusion Criteria: * (a) any known systemic disease, (b) periodontal treatment within the last six months, (c) patients having less than 10 teeth, (d) smokers and (e) individuals with BMI \> 30 kg/m2

Outcomes

Primary Outcomes

Changing MMP-8 levels

Salivary and GCF level measured by IFMA

Time frame: 6 months

Changing MMP-9 levels

Salivary and GCF level measured by ELISA

Time frame: 6 months

Changing TIMP-1 levels

Salivary and GCF level measured by ELISA

Time frame: 6 months

Data from ClinicalTrials.gov

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