Management of Spontaneous Ruptured Hepatocellular Carcinoma

Huazhong University of Science and Technology216 enrolled

Overview

To investigate the best treatment for hepatocellular carcinoma rupture

To investigate the best treatment for hepatocellular carcinoma rupture, transcatheter arterial embolization or partial hepatectomy. Furthermore, to discuss the choice of emergency or staged hepatectomy.

Study Type

OBSERVATIONAL

Enrollment

216

Conditions

Rupture, Spontaneous Rupture Liver Hepatocellular Carcinoma

Interventions

Partial hepatectomyPROCEDURE

Partial hepatectomy was comprised of single or multiple liver resections aiming to excise all macroscopic tumors.

Eligibility

Sex: ALLMin age: 15 YearsMax age: 76 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up Exclusion Criteria: * Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Outcomes

Primary Outcomes

Overall survival of all patients

Overall survival difference between the partial hepatectomy group and the non-surgical group

Time frame: 5 years

Secondary Outcomes

Postoperative peritoneal dissemination

Postoperative peritoneal dissemination diagnosed by imaging examination

Time frame: 5 years

Recurrence-free survival of all patients

Recurrence-free survival difference between the partial hepatectomy group and the non-surgical group

Time frame: 5 years

Overall survival of partial hepatectomy patients

Overall survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group

Time frame: 5 years

Recurrence-free survival of partial hepatectomy patients

Recurrence-free survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group

Time frame: 5 years

Overall survival of staged partial hepatectomy patients

Overall survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group

Time frame: 5 years

Recurrence-free of staged partial hepatectomy patients

Recurrence-free survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group

Time frame: 5 years

Data from ClinicalTrials.gov

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