Pilot study: * Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD) * Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on and off drug conditions, 30 aged matched control subjects and 10 control subjects with supra nuclear palsy * Multi modal approach: functional MRI, clinical , ENT assessment, respiratory assessment, neuropsychological and gait evaluations
Prospective, clinical assessment of : * Cognition and diadochokinetic task during fMRI in 30 PD patients (in off and on condition) * Motor assessment using VICON gait and balance analysis * Pulmonary functional testing in OFF and ON drug condition * Quality of life * Clinical neurological MDS UPDRS , N Fog questionnaire * ENT and speech therapist evaluation in OFF and ON drug condition
Study Type
OBSERVATIONAL
Enrollment
29
Hôpital Roger Salengro, CHRU
Lille, France
Change in the neural network between patients in OFF levodopa conditions and control subjects
Measure evaluated by functional MRI during the realisation of a cognitive task: symbol digit modality test
Time frame: Between two evaluation visits, on average at 3 months (baseline- 3 months)
Change in the neural network between patients in OFF-drug conditions and healthy control subjects
Measure evaluated by functional MRI during the realisation of two motor tasks
Time frame: Between two evaluation visits, on average at 3 months (baseline- 3 months)
Change in the neural network between patients in OFF-drug conditions and healthy control subjects
Measure evaluated by resting state functional MRI
Time frame: Between two evaluation visits, on average at 3 months (baseline- 3 months)
Change in the neural network between OFF-drug condition and ON-drug condition in patients
Measure evaluated by functional MRI, during the realisation of one cognitive task and two motor tasks
Time frame: Between two evaluation visits, on average at 3 months (baseline- 3 months)
Change in the neural network between patients in OFF-drug conditions and neurological control subjects (with supra nuclear palsy)
Measure evaluated by functional MRI, during the realisation of one cognitive task and two motor tasks
Time frame: Between two evaluation visits, on average at 3 months (baseline- 3 months)
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