The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.
Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level \>25 mIU/mL on two occasion \>4 weeks apart. But there still no diagnosis standard of POI in Chinese.The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.
Study Type
OBSERVATIONAL
Enrollment
50,000
Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
RECRUITINGChange of serum FSH levels
the serum FSH levels between day 2 to day 5 of menstrual cycle from date of recruit until the date of study completion or date of twice FSH level \>25mIU/mL, whichever came first.
Time frame: through study completion, an average of 3 months, assessed up to 48 months
Menstruation situation
the length of the menstrual cycle from date of recruit until the date of study completion or date of twice FSH level \>25mIU/mL, whichever came first.
Time frame: through study completion, an average of 3 months, assessed up to 48 months
Change of Antral follicle count
the Antral follicle count between day 2 to day 5 of menstrual cycle from date of recruit until the date of study completion or date of twice FSH level \>25mIU/mL, whichever came first.
Time frame: through study completion, an average of 3 months, assessed up to 48 months
Change of anti-mullerian hormone levels
the anti-mullerian hormone between day 2 to day 5 of menstrual cycle from date of recruit until the date of study completion or date of twice FSH level \>25mIU/mL, whichever came first.
Time frame: through study completion, an average of 3 months, assessed up to 48 months
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