Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/ amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level \>25 mIU/mL on two occasion \>4 weeks apart. Some clinicians and researchers proposed that POI was a progressive disease and there were three stages of POI: occult POI, biochemical POI, overt POI. However, there is lack of reliable indicators to assess the different stages of POI. The present study is to explore the change of menstruation condition, basal follicle-stimulating hormone, anti-müllerian hormone and antral follicle count during the development of POI, and whether those marks can assess the different stages of POI.
Study Type
OBSERVATIONAL
Enrollment
500
Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
the change of serum follicle-stimulating hormone levels
the serum FSH levels between day 2 to day 5 of menstrual cycle
Time frame: Every 3 months from date of recruit until the date of study completion, assessed up to 48 months
the change of menstruation situation
Menstrual cycle
Time frame: Every 3 months from date of recruit until the date of study completion, assessed up to 48 months
the change of serum anti-mullerian hormone levels
the serum anti-mullerian hormone levels between day 2 to day 5 of menstrual cycle
Time frame: Every 3 months from date of recruit until the date of study completion, assessed up to 48 months
the change of antral follicle count
Antral follicle count between day 2 to day 5 of menstrual cycle
Time frame: Every 3 months from date of recruit until the date of study completion, assessed up to 48 months
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