To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese participants with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR) after platinum-based chemotherapy
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
224
60 mg twice daily (BID), orally (per os-PO)
60mg BID, PO
Progression free survival (PFS) by blinded Independent Review Committee (BIRC) assessment
Time frame: up to 8 years
Overall survival
Time frame: up to 9 years
Objective response rate by investigator assessment
Time frame: up to 2 years
Duration of response by investigator assessment
Time frame: up to 2 years
PFS by investigator assessment
Time frame: up to 8 years
Time to response by investigator assessment
Time frame: up to 8 years
Number of participants with treatment-emergent adverse events (TEAEs)
Time frame: up to 9 years
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Anhui Provincial Cancer Hospital Aka West Branch of Anhui Province Hospital
Hefei, Anhui, China
Peking University First Hospital
Beijing, Beijing Municipality, China
Beijing Cancer Hospital
Beijing, Beijing Municipality, China
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Chongqing Cancer Hospital
Chongqing, Chongqing Municipality, China
Southwest Hospital
Chongqing, Chongqing Municipality, China
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College
Shantou, Guangdong, China
The Tumor Hospital Affiliated to Guangxi Medical University
Nanning, Guangxi, China
...and 18 more locations