Sex hormone-binding globulin(SHBG) is a surrogate marker of insulin resistance. This study aims at the characteristic and clinical significance of SHBG and testosterone in patients with type 2 diabetes(T2D).
The investigators recorded clinical factors, biochemical criterion such as serum levels of glucose and lipids, HbA1c, SHBG, testosterone, insulin, EPO, C-peptide, glucagon, microalbuminuria, glycemic variation via CGM, carotid plaque, ECG and ultrasonic cardiogram in patients with T2D who visited in the Department of Endocrinology at the Nanjing First Hospital from January 2015 to Aprol 2018. The relationship between levels of SHBG, testosterone and glycemic variation/diabetic complications are analysed.
Study Type
OBSERVATIONAL
Enrollment
250
sex hormone-binding globulin
the blood sex hormone-binding globulin level of patients
Time frame: Day 1
Testosterone
blood testosterone level of patients
Time frame: Day 1
EPO
blood erythropoietin level of patients
Time frame: Day 1
HbA1c
the glycosylated hemoglobin level of patients
Time frame: Day 1
MBG
24h mean blood glucose tested by CGM
Time frame: Day 1-4
MAGE
the 24h mean amplitude of glycemic excursion
Time frame: Day 1-4
SD
the standard deviation of mean glucose
Time frame: Day 1-4
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