Oxidation-reduction Homeostasis in Cognitive Impairment Patients After Stroke

N/ACompletedNCT03519828

Hui-Sheng Chen100 enrolled

Overview

Cognitive impairment after ischemic stroke can affect not only the social adaptation ability, but also affect the comprehensive rehabilitation of patients. The damage of cognitive impairment after ischemic stroke is not lower than the body function defect after stroke. Many studies have shown that oxidative stress is one of the pathophysiological mechanisms of ischemic cerebrovascular disease. Many studies have reported that the oxidative-reduction of cells plays an important role in the life activities of organisms, affecting the health, aging and death of the organism. In the recent years, some scholars have suggested that post-stroke cognitive impairment may be related to oxidative-reduction homeostasis of the body, but the relevant evidence is lacking and needs to be further explored. Therefore, the purpose of this study is to explore the effect of oxidation-reduction homeostasis on cognitive impairment in patients with ischemic stroke, and provide a theoretical basis for the prevention and treatment of cognitive impairment after ischemic stroke.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Oxidative-reduction Homeostasis Post-stroke Cognitive Impairment

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 40-80 years old; * Ischemic stroke for the first time or previous stroke but with no serious sequelae (mRS is 0 -2 points); * Time from onset to treatment ≤48 hours; * Conscious awareness, and with no obvious aphasia and visual impairment; * Signed informed consent by patient self or legally authorized representatives. Exclusion Criteria: * Intracranial hemorrhage or suspected subarachnoid hemorrhage; * Transient ischemic attack; * Patients with severe mental disorders or language disorders; * Patients can not cooperate with evaluators, such as mental illness or dementia; * Pregnant women or suckers; * Researchers consider patients inappropriate to participate in the registry.

Outcomes

Primary Outcomes

Oxidative-reduction homeostasis in acute ischemic stroke patients

Reduced glutathione (GSH)/ Oxidized glutathione (GSSG), Superoxide dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GSH-PX) of acute ischemic stroke patients will be tested.

Time frame: 1 day

Cognitive function in acute ischemic stroke patients

Mini Mental Status Examination (MMSE) and Montreal cognitive assessment scale (MoCA) in acute ischemic stroke patients will be evaluated.