Diastolic dysfunction is an important cause of hemodynamic instability in the perioperative field.Therefore this study aims to investigate the influence of existing diastolic dysfunction or deterioration of diastolic function on hemodynamic stability during induction of anesthesia and postoperative complications. The impact of different anesthetics on diastolic function is investigated.
In this prospective observational study two cohorts of patients with different anesthesia regimes are investigated. Anesthesia is maintained with sevoflurane or propofol. Before induction of anesthesia a transthoracic echocardiography is performed to examine systolic and diastolic function. Immediately after induction, during maintenance and after completion of anesthesia any changes of diastolic function are examined with transthoracic echocardiography. All anesthetic medications, fluids, vasoactive medications and catecholamines are registered.
Study Type
OBSERVATIONAL
Enrollment
200
Anesthesia maintenance with Sevoflurane
Anesthesia maintenance with Propofol
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Germany
Norepinephrine
Cumulative dose of norepinephrine (adjusted for body weight) during the first 30 minutes after induction of anesthesia
Time frame: 30 minutes after induction of anesthesia
e'
Change of the echocardiographic tissue doppler parameter e' after induction of anesthesia
Time frame: Directly after induction of anesthesia
E / e'
Change of the echocardiographic index of transmitral flow and tissue doppler after induction of anesthesia
Time frame: Directly after induction of anesthesia
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